Mobile/Cloud
Personalized Predictive Health Avatar
To enable the emerging P4 (predictive, preventative, personalized, participatory) medicine CoBi software, typically used for 3D high-fidelity simulations, have been adapted for mobile/cloud fast computing with interfaces to cell phones and tablets. The human body health avatar integrating the anatomy, physiology, systems biology, genetics and pharmacology for specific diseases is the critical component of CoBi P4 medicine. We have developed prototype P4 modules for asthma, COPD, diabetes, glaucoma, psoriasis, opioids addiction and neurotrauma. With our academic partners CoBi based P4 tools are being developed for other diseases including colorectal cancer, respiratory viral infection.
The P4 framework, CoBi-Pulmo, for lung diseases depicted below includes personalized patient body, airways, lungs and the whole body PBPK of inhaled and oral medications as well as pharmacodynamics of drug efficacy and potential adverse effects.
The CoBi multiscale computing engine shown above is invisible to the patient as it is deployed on a cloud computing with direct link to patient’s mobile device and wearable sensors. In the P4 Pulmo framework, shown below, the health and activity sensors, such as the Fitbit, pulse oximeter, spirometer and other devices transmit the data to the cell phone and then, along with time-stamped patient self-reported symptoms, are sent to the cloud database for CoBi analytics. The cell phone App with user friendly disease specific GUI provide the dynamic feedback to the patient and to his physician.
