CoBi-Body tools for generation of 3D human body models using basic anthropometric measurements. The body can be articulated into a desired posture, outfitted with clothing and equipment and used for biodynamic and biomechanics simulations.
CoBi Q3D model of drug release from the oil-in-water micelle suspension formulation.
CoBi multicompartmental whole body PBPK and PD model for the disposition and competitive interaction of opioids and opioid overdose antidotes.
CoBi multicompartmental model of solid particle dissolution and sampling of a solid suspension in a well-mixed vessel. The Noyes-Whitney equation is used to characterize particle dissolution, employing both particle properties and drug physicochemical properties. The model accounts for intermittent pipette sampling or microfluidic flow-based sampling.
CoBi Q3D model of a controlled drug release from a bio-degradable copolymer PLGA microsphere. The model simulates PLGA hydrolysis reaction between ester bonds and diffusing water molecules, the autocatalytic effect arising from the carboxylic acid end groups of the oligomers, and the diffusion of the short-chain oligomers into the surrounding solution.
CoBi Q3D model of the entire GIT simulates the transport of drug formulations, e.g. tablets, controlled release, dissolution, absorption across and metabolism in the barrier.
Dynamic parametric simulation of a drug suspension formulation dissolution and transport across functionalized membrane in a Transwell
CoBi-Blast fast running simulations of blast wave loading on the serviceman involved in heavy weapon training. (Request the login and password to access)